Non-invasive brain stimulation reorganises effective connectivity during a working memory task in individuals with Neurofibromatosis Type 1.

ABSTRACT:

Introduction

In a previous study, we examined the effect of atDCS on working memory task performance and modulation of the inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), in the dorsolateral prefrontal cortex (dlPFC). The present study investigates whether tDCS modulates effective connectivity during the task, specifically assessing whether tDCS alters interactions between neuronal populations.

Methods

Eighteen adolescents with Neurofibromatosis Type 1 (NF1) completed a single-blind sham-controlled cross-over randomised tDCS trial (with the anode at F3 and cathode at Cz). Dynamic causal modelling was used to estimate the effective connectivity between regions that showed working memory effects from the fMRI. Group-level inferences for between sessions (pre- and

SUBMITTER: Litwinczuk MC 

PROVIDER: S-EPMC12172827 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature