ProOvErlap: Assessing feature proximity/overlap and testing statistical significance from genomic intervals.

ABSTRACT: Feature overlap is a critical concept in bioinformatics and occurs when two genomic intervals, usually represented as BED files, are located in the same genomic regions. Instead, feature proximity refers to the spatial proximity of genomic elements. For example, promoters typically overlap or are close to the genes they regulate. Overlap and proximity are also important in epigenetic studies. Here, the overlap of regions enriched for specific epigenetic modifications or accessible chromatin can elucidate complex molecular phenotypes. Consequently, the ability to analyze and interpret feature overlap and proximity is essential for understanding the biological processes that contribute to a given phenotype. To address this need, we present a computational method capable of analyzing data rep

SUBMITTER: Gualandi N 

PROVIDER: S-EPMC12172997 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature