High-fat diet-induced increase in glucocorticoids contributes to adipogenesis in obese mice.

ABSTRACT:

Background

This study was designed to examine how glucocorticoids (GCs) induced by a long-term ingestion of high-fat diet (HFD) mediate the HFD-induced adipose expansion and obesity.

Material and methods

To address this goal, we used a unique L/L mouse model that fails to induce its corticosterone (CORT) level, a major type of GCs in rodents, after prolonged exposure to an HFD.

Results

We found that, after receiving a 12-week HFD feeding, the L/L mice show less weight gain, milder adipose expansion, and higher plasma levels of triglycerides than the wild-type mice. These changes were reversed by replenishing CORT to L/L mice. When examining the expression levels of various molecules linked to lipid uptake and de novo lipogenesis in CORT-induced adipose expansion, we o

SUBMITTER: Tsai SF 

PROVIDER: S-EPMC12173011 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature