A Comparison of Magnetic Resonance Imaging Assessment and Biopsy Outcomes with and Without Central Review in Two Swedish Regional Organized Prostate Cancer Testing Programs.

ABSTRACT:

Background and objective

The European Council advises evaluating the feasibility of organized prostate cancer testing (OPT) programs, but it is unclear whether results from screening trials can be replicated in population-based testing. The aim of this study is to compare magnetic resonance imaging (MRI) assessments and biopsy outcomes with and without a central review in two Swedish OPT programs.

Methods

Two regional population-based OPT programs invited 65 000 men (2020-2022). MRI scans were read locally, and biopsies followed a strict MRI-based and prostate-specific antigen (PSA) density-based protocol. A blinded central review was done by two radiologists with 8 and 9 yr of experience. Reader agreement was assessed with percentages and kappa scores. Positive predictive v

SUBMITTER: Wallstrom J 

PROVIDER: S-EPMC12173033 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature