Targeting EIF4A1 is effective against human intrahepatic cholangiocarcinoma.

ABSTRACT:

Background & aims

Intrahepatic cholangiocarcinoma (iCCA) is the second most frequent primary liver tumor, characterized by clinical aggressiveness, dismal outcome, and limited therapeutic options. Thus, innovative treatments are urgently required to improve the prognosis of patients with iCCA.

Methods

In this study, we determined the pathogenetic and therapeutic role of eukaryotic initiation factor 4A1 (EIF4A1), a subunit of the eIF4F complex involved in translation initiation, in human iCCA.

Results

Preinvasive (n = 12), invasive (n = 162), and metastatic (n = 14) iCCA lesions exhibited ubiquitous eIF4A1 upregulation. In addition, eIF4A1 mRNA levels from 42 specimens showed a significantly higher expression in iCCA samples compared with non-tumorous tissues (<

SUBMITTER: Mi W 

PROVIDER: S-EPMC12173056 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature