Diminished MYCN Dosage Endows Cavitary Transformation in Retinoblastoma.

ABSTRACT:

Objective

Cavitary retinoblastoma (CRB) represents a unique variant of retinoblastoma (RB) distinguished by the presence of translucent cavities, which are discernible through ophthalmoscopic examination. The present study was designed to elucidate the clinical implications and molecular signatures of CRB, thereby enhancing our understanding of this distinct subtype of RB.

Design

A multicentric, nested case-control, retrospective cohort study combining spatial proteomic analysis.

Participants

In a longitudinal study encompassing 1360 RB patients, conducted over a 13-year timeframe from June 2008 to February 2022, cavitary spaces were detected within the tumors of 48 eyes of 46 patients. A control cohort of 180 eyes from 138 age-matched patients with non-CRB was select

SUBMITTER: Xu M 

PROVIDER: S-EPMC12173066 | biostudies-literature | 2025 Sep-Oct

REPOSITORIES: biostudies-literature