Charge balance transition enabled <i>Janus</i> hydrogel for robust wet-tissue adhesion and anti-postoperative adhesion.

ABSTRACT: Janus hydrogels have recently emerged as promising bioadhesives for efficient wet-tissue adhesion and anti-postoperative adhesion. However, existing Janus hydrogel adhesives normally need varied chemical designs of different layers to achieve asymmetric adhesive/anti-adhesive properties on either side. Here, we present a new strategy to construct an adhesive/anti-adhesive Janus hydrogel tissue patch accomplished by switching the charge-balance of the hydrogel layers with similar compositions (anionic carboxyl polymer and cationic ε-polylysine, EPL). The bottom layer (AL) is formed under acidic condition (pH 2.85), featuring abundant -COOH and -NH₃ ⁺ residues, which provide rapid & robust adhesion to diverse wet tissues (up to 100.4 kPa) with high

SUBMITTER: Peng W 

PROVIDER: S-EPMC12173079 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature