Effect of aspirin on small for gestational age neonates in pregnancies at high-risk for preeclampsia: a secondary analysis of a cluster randomised clinical trial.

ABSTRACT:

Background

Data on the effect of 100-160 mg/day aspirin prophylaxis on small for gestational age neonates (SGA) in pregnancies at high-risk for preeclampsia (PE) is limited. We aimed to determine the impact of aspirin administration on the incidence of SGA.

Methods

This is a secondary analysis of a multicenter stepped wedge cluster-randomized trial included 18 maternity/diagnostic units across ten Asian regions between 1st August 2019 and 28th February 2022. The trial started with a period where all recruiting centers provided routine antenatal care without study-related intervention. At six-week intervals, one cluster was randomized to transition from non-intervention phase to intervention phase. In the intervention phase, women identified as high-risk for preterm-PE receiv

SUBMITTER: Chen Y 

PROVIDER: S-EPMC12173081 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature