Liposomes, immune cells, and lung cancer subtypes: A bidirectional Mendelian randomization study.

ABSTRACT: Alterations in lipid metabolism and immune cell functions have gained attention for their impact on the tumor microenvironment. However, the causal relationships between lipids and immune cells in lung cancer subtypes remain unclear. This study utilized plasma lipidomics summary data from genome-wide association studies, immune phenotypic data from the European Bioinformatics Institute, and comprehensive statistics of different lung cancer subtypes from the International Lung Cancer Consortium and the Transdisciplinary Research in Cancer of the Lung (TRICL). Two-sample Mendelian randomization and Bayesian weighted Mendelian randomization were applied to explore causal links between lipids and lung cancer subtypes. Sensitivity tests ensured robustness, and mediation analysis assessed immune

SUBMITTER: Tian K 

PROVIDER: S-EPMC12173287 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature