Integrative bioinformatics analysis of lipid metabolism-related genes and immune infiltration in endometriosis.

ABSTRACT: Endometriosis is referred to as a "benign cancer," severely impacting women's reproductive health. However, the pathogenesis of endometriosis remains unclear. This study aims to investigate the potential roles of lipid metabolism-related genes (LMRGs) and immune infiltration in the diagnosis and pathogenesis of endometriosis. Four microarray datasets (GSE6364, GSE51981, GSE153740, and GSE232713) with eutopic endometrium samples of the midsecretory phase were downloaded from the Gene Expression Omnibus database. Seven hundred forty LMRGs were obtained from the Reactome database. The GSE6364 and GSE51981 datasets were merged and differentially expressed genes (DEGs) were identified between endometriosis patients and normal controls. Lipid metabolism-related DEGs were detected by intersecting

SUBMITTER: Ye X 

PROVIDER: S-EPMC12173326 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature