Risk of ischemic stroke associated with anti-rheumatic agents in patients with rheumatoid arthritis: A nationwide population-based case-control study.

ABSTRACT:

Introduction

Patients with rheumatoid arthritis (RA) face a significantly higher risk of major adverse cardiovascular events, including stroke, due to the pivotal role of inflammation in atherosclerosis and thrombosis. Various anti-rheumatic agents may influence stroke risk either by increasing or decreasing it, and this effect remains unclear. This study aimed to investigate the association between different anti-rheumatic agents and the risk of incident stroke in patients with RA using a nationwide claims database.

Methods

In this nested case-control study, the Korean Health Insurance Review and Assessment data of 35,133 patients newly diagnosed with seropositive RA from January 2011 to December 2020 were used. Incident ischemic stroke cases were identified and matched wit

SUBMITTER: Ahn SM 

PROVIDER: S-EPMC12173416 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature