Automatic motion correction for myocardial blood flow estimation improves diagnostic performance for coronary artery disease in ¹⁸F-flurpiridaz positron emission tomography-myocardial perfusion imaging.

ABSTRACT:

Background

Motion correction (MC) is critical for accurate quantification of myocardial blood flow (MBF) and flow reserve (MFR) from ¹⁸F-flurpiridaz positron emission tomography (PET) myocardial perfusion imaging (MPI). However, manual correction is time consuming and introduces inter-observer variability. We aimed to validate an automatic MC algorithm for ¹⁸F-flurpiridaz PET-MPI in terms of diagnostic performance for predicting coronary artery disease (CAD).

Methods

In total, 231 patients who underwent invasive coronary angiography and rest/pharmacologic stress ¹⁸F-flurpiridaz PET-MPI from the phase III Flurpiridaz trial (NCT01347710) were enrolled. For manual MC, two operators (Reader 1 and Reader 2) shifted each frame's images in three dir

SUBMITTER: Builoff V 

PROVIDER: S-EPMC12173448 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature