Single-cell dissection of prognostic architecture and immunotherap response in <i>Helicobacter pylori</i> infection-associated gastric cancer.

ABSTRACT: Most of the human gastric cancer (GC) worldwide are ascribed to Helicobacter pylori infections, which have a detrimental effect on the immunotherapy's efficacy. Comprehensively dissecting the key cell players and molecular pathways associated with cancer immunotherapies is critical for developing novel therapeutic strategies against H. pylori infection-associated human GC. We performed a comprehensive single-cell transcriptome analysis of nine GC patients with current H. pylori infection (HpGC), three GC patients with previous H. pylori infection (ex-HpGC), six GC patients without H. pylori infection (non-HpGC), and six healthy controls (HC). We also investigated key cell players and molecular pathways associated with GC immunotherapy outcomes. We reveale

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12173458 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature