Adult Patients with HbS-Only Phenotype of Sickle Cell Disease Have a Decreased Arginine/Asymmetric Dimethylarginine Ratio.

ABSTRACT:

Introduction: Leg ulcer is the most common cutaneous manifestation of sickle cell disease (SCD). Asymmetric dimethylarginine (ADMA) inhibits nitric oxide synthase, reducing nitric oxide availability, and causing endothelial dysfunction. This study examined the relationship between arginine/ADMA ratio and leg ulcers in SCD.

Methods

This was a cross-sectional analytical study of 90 adult subjects including 30 "HbS only" with leg ulcer, 30 "HbS only" without leg ulcer and 30 HbAA subjects. Plasma arginine and ADMA levels were measured by ELISA method.

Results

Median arginine level, ADMA level, and arginine/ADMA ratio were 21.05 µmol/L, 3.0 µmol/L, and 7.41, respectively, for HbS-only with leg ulcer; 25.9 µmol/L, 2.8 µmol/L, and 9.6, respectively, for HbS-only without leg ulce

SUBMITTER: Ugwu A 

PROVIDER: S-EPMC12173462 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature