Morphology-engineered alleviation of mycelial aggregation in <i>Streptomyces</i> chassis for potentiated production of secondary metabolites.

ABSTRACT: The genus Streptomyces exhibits a complex life cycle of morphological differentiation and an extraordinary capacity to produce numerous bioactive secondary metabolites. In submerged cultures, Streptomyces species usually grow in the form of mycelial networks and aggregate into large pellets or clumps, which is generally unfavorable for industrial production. This study aimed to construct efficient microbial cell factories by manipulating morphology-related genes. We herein employed a morphology engineering approach to generate eight engineered derivatives (MECS01∼MECS08) of Streptomyces coelicolor M1146, a versatile chassis widely used for the heterologous production of various secondary metabolites. We found that genetic manipulation of morphology-related genes exerte

SUBMITTER: Liu S 

PROVIDER: S-EPMC12173525 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature