Mendelian randomization analysis reveals causal relationship between allergic diseases and influenza.

ABSTRACT:

Background

Allergic diseases and influenza share similar genetic backgrounds and pathophysiological mechanisms. Observational studies have established a correlation between these 2 conditions; however, the precise direction of the causal relationship remains unclear. This Mendelian randomization (MR) study aims to evaluate the causal relationship between allergic diseases and influenza.

Materials and methods

This study utilized summary statistical data from genome-wide association studies (GWAS) and employed the two-sample MR method to comprehensively analyze the causal relationships between allergic diseases (asthma, hay fever, eczema), atopic dermatitis (AD), hay fever or allergic rhinitis (AR), and different types of influenza (including all influenza, regular influenza e

SUBMITTER: Li H 

PROVIDER: S-EPMC12173599 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature