Silicon-enriched meat consumption mitigates brain cortex damage associated with diabetic dyslipidemia in a late-stage type 2 diabetes mellitus rat model.

ABSTRACT: Neuroprotective properties of silicon have been reported, particularly in mitigating dementia and Alzheimer's disease due to its ability to reduce aluminum bioavailability. However, its potential as a nutritional adjuvant in reducing brain damage associated with hypercholesterolemia and central insulin resistance (IR) in late-stage type 2 diabetes mellitus (T2DM) remains unexplored. This study aimed to evaluate the effects of silicon-enriched meat (Si-RM) on the brain cortex of T2DM rats. Rat models of early-stage-T2DM (ED) (n = 8) and late-stage-T2DM (LD) (n = 16) were induced by high-saturated fat diet and high-saturated fat high-cholesterol diet plus streptozotocin/nicotinamide injection, respectively. A control meat (C-RM) was included in the diet of both ED and LD groups. Finally, aft

SUBMITTER: Redondo-Castillejo R 

PROVIDER: S-EPMC12173608 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature