Insula under the influence: Alcohol-induced changes in resting state functional connectivity.

ABSTRACT:

Background

The insular cortex (IC), which includes anterior (AIC) and posterior (PIC) subdivisions, plays a role in numerous functions and behaviors, including chronic alcohol consumption. This study investigated acute alcohol effects on functional connectivity (FC) of the IC in healthy social drinkers. We hypothesized that acute alcohol consumption would significantly disrupt IC resting-state FC (rsFC) with the whole brain and would differentially modulate the rsFC of the AIC and PIC. This study also examined the association of alcohol-induced changes in IC rsFC with subjective intoxication and whether sex and family history of alcohol problems moderate the effect of acute alcohol intake on IC rsFC.

Methods

One hundred and seven healthy social drinkers (25-45 years) complet

SUBMITTER: Cushnie AK 

PROVIDER: S-EPMC12173802 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature