Role of CD28⁺ PD-1⁺ Tc cells in immune response and prognosis prediction in hepatocellular carcinoma.

ABSTRACT:

Background

CD28⁺PD-1⁺ Tc cells (CD8⁺ T cells) constitute a dysfunctional subset of T cell; however, the mechanisms underlying their dysfunction and their significance in hepatocellular carcinoma (HCC) remain unclear. We aimed to elucidate the prognostic significance and molecular characteristics of CD28⁺PD-1⁺ Tc cell infiltration in HCC.

Methods

We established a single-cell HCC transcriptional map, focusing on cell-cell communication and trajectory analysis of CD28⁺PD-1⁺ Tc cells. We assessed the correlation between CD28⁺PD-1⁺ Tc-cell enrichment and prognosis and investigated potential molecular mechanisms using enrichment analyses. Flow cytometry was used to compare CD28⁺

SUBMITTER: Yang W 

PROVIDER: S-EPMC12174045 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature