The RNF/NQR redox pumps: a versatile system for energy transduction in bacteria and archaea.

ABSTRACT: The Na⁺ (or H⁺)-translocating ferredoxin:NAD⁺ oxidoreductase (also called RNF, rhodobacter nitrogen fixation, complex) catalyzes the oxidation of reduced ferredoxin with NAD⁺, hereby generating an electrochemical gradient. In the reverse reaction driven by an electrochemical gradient, RNF provides reduced ferredoxin using NADH as electron donor. RNF plays a crucial role in the metabolism of many anaerobes, such as amino acid fermenters, acetogens, or aceticlastic methanogens. The Na⁺-translocating NADH:quinone oxidoreductase (NQR), which has evolved from an RNF, is found in selected bacterial groups including anaerobic, marine, or pathogenic organisms. Since NQR and RNF are not related to eukaryotic respiratory complex I (NADH:quinone

SUBMITTER: Buckel W 

PROVIDER: S-EPMC12174285 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature