Fabrication and evaluation of carbonate apatite granule sponges using fish-derived collagen for advanced synthetic bone substitutes.

ABSTRACT: Carbonate apatite (CO₃Ap) granules have been employed as advanced bone substitutes owing to their capacity to remodel into new natural bone, aligning with the bone remodeling process. Their application spans dental clinical fields in both Japan and the US. Nonetheless, owing to the granular nature of CO₃Ap, certain challenges in the application of these materials can arise, such as intraoperative scattering and postoperative migration. To address these issues, we integrated CO₃Ap granules with collagen to generate a sponge-like composite. Collagen, typically derived from bovine or porcine sources, is commonly utilized in clinical settings despite the potential for infections, including parasitic zoonosis. For the purposes of this study, we selected fish-der

SUBMITTER: Kudoh K 

PROVIDER: S-EPMC12174302 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature