Role of ADME genes in breast cancer prognosis: an analysis of risk scoring models based on multi-omics data.

ABSTRACT:

Background

Breast cancer (BC) is a significant malignancy characterized by a high global incidence and a propensity for recurrence. Absorption, distribution, metabolism, and excretion (ADME) genes comprise a collection of genes that participate in the drug ADME. Understanding the role and prognostic value of ARGs (ADME related genes) in BC advancement is critical for personalized therapy. Therefore, an ARPS (ADME related prognostic signature) was created in this study to examine the clinical implications of ARGs in patients with BC.

Methods

A multi-omics investigation of ADME-related genes in BC was conducted using bulk RNA sequencing, single-cell RNA sequencing, and spatial transcriptome data. According to the expression profiles of ADME-related differentially expressed gen

SUBMITTER: Jin J 

PROVIDER: S-EPMC12174373 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature