Influence of chronic alcohol consumption on cerebral ischemia/reperfusion injury in female mice.

ABSTRACT: Light alcohol consumption (LAC) protects against cerebral ischemia/reperfusion (I/R) injury, whereas heavy alcohol consumption (HAC) worsens it in male mice. The phenomenon appeared to be associated with the dose-dependent influence of alcohol on cerebral angiogenesis and post-ischemic inflammation. However, whether there is a sex-specific difference is unknown. Therefore, the goal of this study was to examine the influence of chronic alcohol consumption on cerebral I/R injury in female mice. Female C57BL/6J mice were gavage-fed with 0.7 g/kg/day ethanol (designed as LAC), 2.8 g/kg/day ethanol (designed as HAC), or volume-matched water (designed as control) for 8 weeks. Subsequently, they were subjected to unilateral middle cerebral artery occlusion (MCAO) for 60 min. Under basal condition

SUBMITTER: Subedi U 

PROVIDER: S-EPMC12174416 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature