Polymorphisms in circadian rhythm genes and the risk of differentiated thyroid cancer.

ABSTRACT:

Introduction

Circadian rhythms are controlled by biological clocks regulated at the molecular level by a set of circadian genes operating through a negative feedback loop. These genes also regulate key biological processes, including cell proliferation, cell cycle, and apoptosis.

Methods

We investigated the role of circadian gene polymorphisms in the risk of differentiated thyroid cancer (DTC) and their interaction with DTC risk factors. Data were obtained from 463 DTC cases and 482 unrelated controls of European ancestry, selected from two population-based case-control studies conducted in France. Associations with 570 single nucleotide polymorphisms (SNPs) in 23 circadian genes were evaluated using multivariate logistic regression models. Gene- and pathway-level associatio

SUBMITTER: Berrandou TE 

PROVIDER: S-EPMC12174421 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature