Aging induces T cells with distinct transcriptomic profiles and functions in brain-associated tissues.

ABSTRACT:

Background

Aging is known to induce the emergence of distinct lymphocyte populations with unique molecular and functional characteristics. However, the impact of aging on the transcriptomes and functional activities of CD4 and CD8 T cells in non-lymphoid tissue remains poorly understood. Investigating aging-induced transcriptomic changes in tissue-infiltrating immune cells may provide insights into tissue homeostasis and malignancy in the aging context.

Methods

Single-cell RNA sequencing (scRNA-seq) was performed to compare the cell subsets and transcriptomes of CD4⁺ and CD8⁺ T cells in brain-associated tissue, including the meninges and choroid plexus of young and aged mice. Flow cytometry was used to analyze aging-associated CD4⁺ T cells in

SUBMITTER: Si Y 

PROVIDER: S-EPMC12174455 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature