Adenosine Triphosphate - Binding Cassette Transporter A1 gene polymorphism (rs1800977 and rs2230806) analysis in Oral Premalignant Disorder of South Indian Cohort.

ABSTRACT:

Objective

To evaluate the association between the ABCA1 upstream variant rs1800977 (G/A) and the missense variant rs2230806 (C/T) with oral premalignancies such as oral submucous fibrosis and leucoplakia.

Methods

The rs1800977 and rs2230806 of ABCA1 were analysed using PCR-RFLP in 350 subjects including OSMF, leukoplakia and healthy controls matched with age, sex, and chewing or smoking habitual factors. The allele frequency distribution and genotypic association for homozygous wild, heterozygous and variant for the diseased groups and healthy control were examined. The influence of rs1800977 and rs2230806 on mRNA secondary structure, gene-gene and protein-protein interactions was examined.

Results

The prevalence of chewers and smokers was 67% and 58% in OSMF and leuk

SUBMITTER: Subbiah U 

PROVIDER: S-EPMC12174518 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature