Dopamine Transporter Imaging as Objective Monitoring Biomarker in Parkinson's Disease.

ABSTRACT:

Objective

Although dopamine transporter (DaT) imaging is a valuable diagnostic biomarker, few studies have investigated its utility in objectively monitoring disease progression in patients with Parkinson's disease (PD). To date, no study has established a longitudinal relationship between the DaT signal decline and the motor symptom increase, potentially due to neglected factors such as brain regions, disease laterality, and symptom subtypes, which this study addresses.

Methods

This cohort study included participants who met the Movement Disorder Society (MDS) criteria for PD, with longitudinal imaging and clinical data from the Parkinson's Progression Markers Initiative Database. Linear mixed model analyses were used to investigate the relationship between the DaT signal d

SUBMITTER: Dzialas V 

PROVIDER: S-EPMC12174767 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature