Immunoinformatics-Aided Design of a Multiepitope Vaccine Against <i>Eimeria Tenella</i>-Associated Chicken Coccidiosis.

ABSTRACT: Avian coccidiosis, caused by Eimeria protozoa, presents a significant threat to poultry, with Eimeria tenella being particularly harmful due to its impact on the chicken cecum. Growing resistance to current treatments necessitates alternative therapeutic approaches. Consequently, this study employed an immunoinformatics approach to design a multiepitope vaccine targeting E tenella. Key proteins, including the sporulated oocyst TA4 antigen, alkylglycerone-phosphate synthase, and apical membrane antigen-1, were analysed for epitope prediction. Further comprehensive downstream analysis identified 13 MHC class I, 6 MHC class II, and 7 B-cell epitopes, which were linked with suitable linkers. Also, cholera toxin subunit B was incorporated as an adjuvant, creating a 531-amino-acid

SUBMITTER: Fadahunsi AI 

PROVIDER: S-EPMC12174798 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature