Single-cell RNA sequencing analysis of intrahepatic cholangiocarcinoma reveals SPP1 facilitates disease progression via interaction with CD4⁺ T cells.

ABSTRACT: Intrahepatic cholangiocarcinoma (ICC) is an aggressive form of cancer, characterized by limited treatment options and a poor prognosis. Immunological therapy is an emerging and promising strategy that has the potential to enhance treatment outcomes and extend the survival of patients with ICC. The role of CD4⁺ T cells in the development of cancer has attracted attention in previous years. However, the complexities of the tumor microenvironment (TME) impede the full understanding of the roles of CD4⁺ T cells in cancer. The present study used single-cell RNA sequencing to explore the heterogeneity of the TME during the development of ICC. The results demonstrated that CD4⁺ T cells were enriched in the TME of ICC and the ratio of regulatory T cells (CD4-forkhe

SUBMITTER: Lin X 

PROVIDER: S-EPMC12175135 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature