Unveiling genetic and biological links: exploring the intersection of autoimmune and psychiatric disorders.

ABSTRACT:

Background

A substantial body of observational evidence suggests the genetic link between autoimmune system diseases and psychiatric disorders. However, the shared genetic mechanisms remain largely unclear. This study aims to systematically explore these genetic correlations and identify potential therapeutic targets through integrative bioinformatics analyses.

Methods

We conducted a comprehensive analysis by integrating genome-wide association study (GWAS) summary data from public databases, including 15 autoimmune diseases and 8 psychiatric disorders. We examined genome-wide and regional genetic correlations and overlaps between these disorders using LDSC, HDL, LAVA, and GPA. Potential pleiotropic single nucleotide variants (SNVs) were identified through PLACO analysis. FU

SUBMITTER: Liwayiding A 

PROVIDER: S-EPMC12175323 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature