Kruppel-like factor 9 may regulate the inflammatory injury of chondrocytes by affecting NF-κB signaling.

ABSTRACT:

Background

Kruppel-like factor 9 (KLF9) is involved in the development of osteoarthritis (OA), which is a chronic joint disorder. However, the pathogenesis of OA remains unclear. This study aimed to investigate the relationship between KLF9 and the pathogenesis of OA.

Methods

KLF9 expression in the Gene Expression Omnibus database was analyzed, and the most significantly upregulated and downregulated genes were visualized using a volcano map. Analyses were performed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes to determine the most significantly changed genes. Interleukin-1 beta (IL-1β) was applied to CHON-001 cells and human synovial cells (HSyCs) to establish an OA in vitro cell model. Real-time quantitative polymerase chain reaction (RT-qPCR) and wester

SUBMITTER: Gu H 

PROVIDER: S-EPMC12175337 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature