Utility of type 1 diabetes genetic risk score in a non-European population: insights from an Iranian cohort.

ABSTRACT:

Background

The present study aimed to investigate the efficiency of the type 1 diabetes genetic risk score (T1D GRS) in distinguishing between patients with type 1 and type 2 diabetes in Iran, an underrepresented population in genomic research.

Methods

We included 13,318 participants in the Tehran-Cardiometabolic Genetic Study (TCGS) cohort, classified into individuals without diabetes, with pre-diabetes, with type 2 diabetes, and with type 1 diabetes. Two T1D GRSs and one T2D GRS were calculated and compared between groups using the Wilcoxon test. The ability of genetic risk scores to discriminate T1D and T2D was assessed using the pROC package.

Results

Both T1D GRSs displayed significantly higher scores in the T1D group than in other groups. Notably, T1D GRS2 effect

SUBMITTER: Moazzam-Jazi M 

PROVIDER: S-EPMC12175377 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature