Sedation and analgesia in post-cardiac arrest care: a post hoc analysis of the TTM2 trial.

ABSTRACT:

Background

The routine use of sedation and analgesia during post-cardiac arrest care and its association with clinical outcomes remain unclear. This study aimed to describe the use of sedatives and analgesics in post-cardiac arrest care, and evaluate associations with good functional outcome, survival, clinical seizures, and late awakening.

Methods

This was a post hoc analysis of the TTM2-trial, which randomized 1900 out-of-hospital cardiac arrest patients to either normothermia or hypothermia. In both groups, deep sedation (Richmond Agitation and Sedation Scale ≤ -4) was mandatory during the 40-h intervention. Cumulative doses of sedatives and analgesic drugs were recorded within the first 72 h from randomization. Outcomes were functional outcome (modified Rankin Scale) and

SUBMITTER: Ceric A 

PROVIDER: S-EPMC12175406 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature