Increased GPR35 expression is correlated with poor prognosis in prostate cancer.

ABSTRACT:

Background

G-protein-coupled receptor 35 (GPR35) has been reported to be overexpressed in several types of human cancers, playing essential roles in tumorigenesis and development. However, its expression and prognostic value in Prostate cancer (PCa) remain unclear. This study aims to investigate the expression of GPR35 and its prognostic value in PCa.

Methods

The expression of GPR35 was analyzed using the public database and validated by immunohistochemistry (IHC) in PCa tissues. Subsequently, the correlation between GPR35 expression and the clinical characteristics was evaluated using the Chi-squared test. Kaplan-Meier and Cox proportional hazards regression models were used to analyze the data. Hazard Ratios (HR) and 95% confidence intervals (CI) were calculated for each f

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12175426 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature