A genome-wide SNP-SNP interaction analysis exploring novel interacting loci associated with the risk of recurrence in colorectal cancer.

ABSTRACT:

Background

Genetic factors can influence and predict patient outcomes. The association of interactions of germline SNPs with patient outcomes is an understudied area of prognostic research. In this study, we applied the first genome-wide SNP-SNP interaction analysis in relation to colorectal cancer outcomes.

Objectives

Our objective was to explore interacting SNP loci at the genome-wide level that predict the risk of local or distant recurrence (RMFS) in a cohort of stage I-III colorectal cancer patients from the Canadian province of Newfoundland and Labrador.

Methods

The patient cohort consisted of 430 unrelated Caucasian patients. Genetic and medical data was collected previously and the genetic data consisted of a total of 384,415 genotyped SNPs. The PLINK epistasi

SUBMITTER: Curtis AA 

PROVIDER: S-EPMC12176161 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature