Sarcopenia and Risk of Cognitive Impairment: Cohort Study and Mendelian Randomization Analysis.

ABSTRACT:

Background

Over half the people over 60 years of age experience cognitive impairment, with limited treatment options, making it crucial to identify risk factors. Studies have examined the association between sarcopenia and cognitive impairment; however, the evidence is inconclusive and cannot be used to make causal inferences.

Objective

This study aims to appraise the causal association of sarcopenia with cognitive impairment by triangulating the data from a cohort study and Mendelian randomization (MR) analysis.

Methods

Using UK Biobank data, we first examined the associations of sarcopenia and its indices (appendicular lean mass [ALM], handgrip strength, and gait speed) with cognitive function (fluid intelligence and prospective memory) by using mixed-effects regres

SUBMITTER: Sha T 

PROVIDER: S-EPMC12176244 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature