Cryobiopsy-Based Tri-Modality Sampling Using an Ultrathin Bronchoscope for the Diagnosis of Peripheral Lung Lesions: A Prospective Observational Study.

ABSTRACT:

Introduction

Transbronchial lung biopsy using radial probe endobronchial ultrasound (RP-EBUS) is an important modality for diagnosing peripheral lung lesions (PLLs), but unmet needs remain. This study evaluates the diagnostic yields and safety of cryobiopsy-based tri-modality sampling using an ultrathin bronchoscope (UTB) with RP-EBUS for diagnosing PLLs.

Methods

This prospective observational pilot study was conducted from November 2023 to January 2024, and included patients with PLLs ≤30 mm in diameter. Bronchoscopic procedures were performed using a UTB guided by RP-EBUS. Tri-modality sampling was sequentially conducted using cryobiopsy, forceps biopsy, and transbronchial needle aspiration (TBNA). The primary outcome was cumulative diagnostic yield, and secondary outcomes

SUBMITTER: Seong H 

PROVIDER: S-EPMC12176350 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature