Domain-specific cognitive impairment is differentially affected by Alzheimer disease tau pathologic burden and spread.

ABSTRACT: Tau pathology in Alzheimer disease (AD) is often evaluated in regions associated with episodic memory impairment. However, heterogeneous spreading patterns of tau are observed and correspond to impairment in different cognitive domains. We have previously developed a metric to quantify tau spread extent that is robustly sensitive to atypical spreading patterns. Here, we evaluate tau spread relative to domain-specific and general cognitive impairments during early stages of AD. In total, 529 participants with baseline tau positron emission tomography (PET) and neuropsychological testing were separated into disease-stage groups based on amyloid PET positivity and clinical status via Clinical Dementia Rating^® (CDR^®). General cognition was assessed using the Knight Precli

SUBMITTER: Doering S 

PROVIDER: S-EPMC12176422 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature