Long-Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population-Based Prospective Cohort and a Case-Control Study.

ABSTRACT:

Background

Antibiotics in childhood are commonly used and have been linked to gut microbiome dysbiosis and metabolic disorders. However, direct evidence regarding the association between long-term or recurrent antibiotic use (LRAU) during early life and diabetes was scarce. We performed this study to investigate this association in two population-based studies.

Methods

We undertook a prospective analysis encompassing 147 010 participants from the UK Biobank. Cox proportional hazard regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of self-reported LRAU during early life on diabetes risk. We also conducted a case-control study within the Chinese population, in which 263 diabetes cases and 526 controls were matched for age and living locat

SUBMITTER: Li Z 

PROVIDER: S-EPMC12176498 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature