Imaging-based assessment of response to olaparib in platinum-sensitive relapsed ovarian cancer patients.

ABSTRACT:

Background

High-grade serous carcinoma is a highly metastatic disease with a limited longterm disease control from systemic anti-cancer treatment, for which the radiological treatment response assessment metrics are imprecise. In this work, we developed noninvasive imagingbased measurements of spatial and longitudinal heterogeneity in a retrospective analysis of a phase 2 non-randomized study of germline BRCA1/BRCA2 mutated (gBRCAm) ovarian cancer patients treated with combination of PARP inhibitors (PARPi) and immune checkpoint inhibitors (ICIs).

Methods

Lesions identified in CT images at baseline, week 4 (after PARPi only) and week 12 (after 8 weeks of PARPi + ICIs) were manually segmented. Anatomical networks of the metastatic sites were constructed to represent patterns

SUBMITTER: Delgado-Ortet M 

PROVIDER: S-EPMC12176557 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature