Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics.

ABSTRACT: Blood vessels expand and contract actively as they continuously experience dynamic external stresses from blood flow. The mechanical response of the vessel wall is that of a composite material: its mechanical properties depend on its cellular components, which change dynamically as the cells respond to external stress. Mapping the relationship between these underlying cellular processes and emergent tissue mechanics is an ongoing challenge, particularly in endothelial cells. Here we assess the mechanics and cellular dynamics of an endothelial tube using a microstretcher that mimics the native environment of blood vessels. The characterization of the instantaneous monolayer elasticity reveals a strain-stiffening, actin-dependent and substrate-responsive behaviour. After a physiological pres

SUBMITTER: Dessalles CA 

PROVIDER: S-EPMC12176649 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature