PRDM16-dependent antigen-presenting cells induce tolerance to gut antigens.

ABSTRACT: The gastrointestinal tract is continuously exposed to foreign antigens in food and commensal microorganisms with potential to induce adaptive immune responses. Peripherally induced T regulatory (pT_reg) cells are essential for mitigating inflammatory responses to these agents^1-4. Although RORγt⁺ antigen-presenting cells (APCs) have been shown to programme gut microbiota-specific pT_reg cells^5-7, their definition remains incomplete, and the APC responsible for food tolerance has remained unknown. Here we identify an APC subset that is required for differentiation of both food- and microbiota-specific pT_reg cells and for establishment of oral tolerance. Development and function of these APCs require expression of the transcripti

SUBMITTER: Fu L 

PROVIDER: S-EPMC12176658 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature