Association of Emotional Stress and Adaptive Behavior with Stroke Risk: A Mendelian Randomization Study.

ABSTRACT: Although emotional stress and adaptive behavior are known to influence cardiovascular health, direct evidence linking them to stroke remains limited. This study aims to clarify the associations between emotional stress, adaptive behaviors, and the risk of stroke. We conducted a two-sample Mendelian randomization analysis using data from the UK Biobank, the European Bioinformatics Institute, the Integrative Epidemiology Unit, and the FinnGen project. Indirect effects were estimated using the product of coefficients method. Low satisfaction with family relationships was associated with increased risks of all stroke and ischemic stroke. Mood swings were linked to higher risks of all stroke, ischemic stroke, and large-artery stroke, while feelings of tension were associated with large-artery s

SUBMITTER: Liu J 

PROVIDER: S-EPMC12176705 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature