LKB1 regulates ILC3 postnatal development and effector function through metabolic programming.

ABSTRACT:

Introduction

Group 3 Innate Lymphoid Cells (ILC3s) are important for maintaining intestinal homeostasis and host defense. Emerging studies have shown that metabolic regulation plays a crucial role in regulating ILC3 activation and function. However, the role of Liver Kinase B1 (LKB1), a key metabolic regulator, in regulating ILC3 function and intestinal immunity remains poorly understood.

Methods

To investigate the role of LKB1 in intestinal ILC3s, we generated LKB1 conditional knockout mice by crossing Rorc ^cre and Stk11 ^flox/flox mice. Cell number and cytokine production was examined using flow cytometry. Citrobacter rodentium infection model were used to determine the role of LKB1 in intestinal defense. RT-qPCR, flow cytometry an

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12176730 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature