High-expression of BCL10 inhibits cell-mediated immunity within the tumor immune microenvironment.

ABSTRACT:

Background

B-cell lymphoma 10 (BCL10) is a key signaling molecule that plays a pivotal role in activating the NF-κB signaling pathway. However, it is unclear whether prolonged activation of BCL10 within tumors lead to T cell exhaustion and suppress immune responses against cancer.

Methods

In this study, through multi-layered bioinformatics analysis and experimental verification, the role of BCL10 on immune cells in the tumor immune microenvironment was systematically investigated. The correlation between BCL10 expression and infiltrated immune cells was analyzed by immune algorithms such as xCELL, CIBERSORT, QUANTISEQ and MCPcounter using TCGA and GTEx databases. Furthermore, single-cell RNA sequencing data of the cervical squamous cell carcinoma(CESC)microenvironment were a

SUBMITTER: Gu J 

PROVIDER: S-EPMC12176738 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature