Aqueous extracts of <i>Portulaca oleracea</i> L. alleviate atopic dermatitis by restoring skin barrier function.

ABSTRACT:

Background

Portulaca oleracea L. (PO) is an edible plant with a long medicinal history in traditional Chinese medicine for various inflammatory diseases, including skin disorders such as atopic dermatitis (AD). However, the anti-inflammatory effects and AD-alleviating mechanisms of PO remain unclear.

Methods

PO aqueous extract was prepared from a water-soluble portion and then mixed with carbomer to obtain a hydrogel, which provided stable drug permeation and absorption in mouse skin. Amantadine acetate was identified as an abundant ingredient and further predicted to be a Janus kinase 1 (JAK1) inhibitor via molecular binding simulation. Mice with AD, established by repeated sensitization with 2,4-dinitrochlorobenzene (DNCB), were topically treated with PO hydr

SUBMITTER: Wei H 

PROVIDER: S-EPMC12176770 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature