1,8-Cineole inhibits platelet-leukocyte aggregate formation by reducing P-selectin expression.

ABSTRACT:

Introduction

Platelets, traditionally recognized for their role in hemostasis, have increasingly been implicated in cancer progression, including head and neck squamous cell carcinoma (HNSCC). Beyond releasing growth factors and chemokines, platelets modulate leukocyte-mediated proinflammatory responses and effector functions through direct or indirect contact. These processes promote tumor cell proliferation, survival, epithelial to mesenchymal transition (EMT) and extravasation. Consequently, targeting platelet-leukocyte aggregate (PLA) formation represents a promising pharmacological strategy to interfere with platelet-mediated pro-tumorigenic effects. 1,8-cineole, a plant-derived metabolite found in several botanical sources, has shown potent anti-platelet effects through modul

SUBMITTER: Petry J 

PROVIDER: S-EPMC12176828 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature