The effect of once-weekly insulin icodec vs once-daily basal insulin on physical activity-attributed hypoglycaemia in type 2 diabetes: a post hoc analysis of ONWARDS 1-5.

ABSTRACT:

Aims/hypothesis

Physical activity increases the risk of hypoglycaemia in individuals with type 2 diabetes when basal or basal-bolus insulin therapy is administered. Once-weekly basal insulins may elevate the risk of physical activity-attributed hypoglycaemia compared with other basal insulins because the administered levels cannot be reduced in anticipation of increased physical activity. This post hoc analysis of five separate randomised trials (ONWARDS 1-5) aimed to examine physical activity-attributed hypoglycaemic episodes in adults with type 2 diabetes receiving either once-weekly basal insulin icodec (herein referred to as 'icodec') or once-daily basal insulins.

Methods

The ONWARDS 1-5 Phase 3a randomised controlled trials compared the efficacy and safety of once-weekl

SUBMITTER: Riddell MC 

PROVIDER: S-EPMC12176998 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature