Inherited thrombophilias and stillbirth: a systematic review and meta- analysis.

ABSTRACT:

Purpose

The association between inherited thrombophilias and stillbirth has been long investigated but the estimated risk remains unknown. The aim of our study is to summarize available data on the effect of Factor V Leiden, Prothrombin G20210A and MTHFR mutation, Protein S, Protein C and Anithrombin deficiency on the prevalence of stillbirth.

Methods

We conducted a systematic review and meta- analysis of all relevant available PubMed, Embase and Cochrane studies until February 2024. A sensitivity analysis of only prospective and retrospective studies was performed.

Results

Based on 31 included studies, Factor V Leiden and Prothrombin G202110A mutations, significantly rise the prevalence of stillbirth with a pooled OR 2.35 (95% CI 1.74-3.17) and 2.62 (95% CI 1.79-3.84

SUBMITTER: Delis M 

PROVIDER: S-EPMC12177024 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature