An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variant.

ABSTRACT:

Background

The SARS-CoV-2 Omicron BA.2.86 variant and its descendant lineages, including JN.1, are rapidly spreading globally. We developed mRNA encoding the SARS-CoV-2 RBD derived from XBB.1.5 (XBB.1.5-type LNP-mRNA-RBD), in line with WHO recommendations. Many individuals have acquired immunity specific to the ancestral SARS-CoV-2 strain or early Omicron variants, such as BA.1, BA.2, or BA.5, through natural infection and/or vaccination. However, the efficacy of XBB.1.5-type LNP-mRNA-RBD boost vaccination against a clinical isolate of JN.1 remains uncertain.

Methods

In this study, we used a small amount of LNP-mRNA-RBD as a prime dose compared with a booster shot to mimic the waning immunity against the ancestral and BA.4/5 strains. We immunised female mice with XBB.1.5-typ

SUBMITTER: Uraki R 

PROVIDER: S-EPMC12177156 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature